Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Nephrotic syndrome
ADR ID BADD_A03027
ADR Hierarchy
20      Renal and urinary disorders
20.05      Nephropathies
20.05.01      Glomerulonephritis and nephrotic syndrome
20.05.01.002      Nephrotic syndrome
Description A disorder characterized by symptoms that include severe edema, proteinuria, and hypoalbuminemia; it is indicative of renal dysfunction. [CTCAE] Pathological processes of the KIDNEY without inflammatory or neoplastic components. Nephrosis may be a primary disorder or secondary complication of other diseases. It is characterized by the NEPHROTIC SYNDROME indicating the presence of PROTEINURIA and HYPOALBUMINEMIA with accompanying EDEMA. [MeSH]
MedDRA Code 10029164
MeSH ID D009401; D009404; D009404
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Nephrosis | Nephrosis osmotic | Nephrotic syndrome | Nephrotic syndrome in diseases classified elsewhere | Nephrotic syndrome with lesion of membranoproliferative glomerulonephritis | Nephrotic syndrome with lesion of membranous glomerulonephritis | Nephrotic syndrome with lesion of minimal change glomerulonephritis | Nephrotic syndrome with lesion of proliferative glomerulonephritis | Nephrotic syndrome with other pathological lesion in kidney | Nephrotic syndrome with other specified pathological lesion in kidney | Nephrotic syndrome with unspecified pathological lesion in kidney | Syndrome nephrotic | Nephrotic syndrome worsened | Steroid-resistant nephrotic syndrome | Nephroses
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Not AvailableNot AvailableNot Available
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01941Rilpivirine hydrochloride--
BADD_D01954Rivaroxaban--
BADD_D01971Rosuvastatin0.000177%
BADD_D02022Silvadene--
BADD_D02028Sirolimus--
BADD_D02033Sodium aurothiomalate--
BADD_D02053Sofosbuvir0.001447%
BADD_D02058Sorafenib0.001332%
BADD_D02071Streptomycin0.000106%
BADD_D02090Sulfadiazine--
BADD_D02091Sulfamethoxazole--
BADD_D02093Sulfasalazine0.003454%
BADD_D02097Sulindac--
BADD_D02100Sunitinib0.003197%
BADD_D02101Sunitinib malate--
BADD_D02105Tacrolimus0.012774%
BADD_D02155Tenofovir disoproxil0.026658%
BADD_D02215Ticlopidine--
BADD_D02216Ticlopidine hydrochloride--
BADD_D02223Tiopronin0.000856%
BADD_D02257Trametinib0.000533%
BADD_D02264Trastuzumab--
BADD_D02287Trimethadione--
BADD_D02367Voltaren--
BADD_D02369Voriconazole0.039934%
BADD_D02392Zoledronic acid0.039365%
BADD_D02414Mesalazine0.001275%
BADD_D02424Valaciclovir0.000241%
BADD_D02459Dalteparin0.012704%
BADD_D02470Nintedanib0.000139%
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